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. 2023 Mar 7;39(10):1469–1480. doi: 10.1007/s12264-023-01037-6

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© Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 3 — Expression pattern of ASD risk genes among different cell types. A Clustering of single-cell RNA-seq data from different brain regions. Cell types are colored differently. B Visualization of enrichment scores of the 55 High-impact genes by UMAP. C Visualization of enrichment scores of the 165 Moderate-impact genes by UMAP. D Heatmap showing averaged enrichment scores of ASD risk genes among the different subtypes (high, red; low, blue). The top three most enriched cell types for each gene set are shown on the sidebar. E Histogram showing the proportion of highly expressed genes (genes expressed in at least 25% of cells in an individual cell type) of the 55 High-impact genes among cell types. F Histogram showing the proportion of highly expressed genes (genes expressed in at least 25% of cells in an individual cell type) of the 165 Moderate-impact genes among cell types.