Table 3.
Safety tests performed evaluating predatory bacteria
| Animal host | Tested cells (organ or organelle) | Loss in vitality? | References |
|---|---|---|---|
| Bovine | Madin–Darby bovine kidney (MDBK) cells | –a | Boileau et al. (2011) |
| Chick | Gut (Oral gavage) | – | Atterbury et al. (2011) |
| Human | HaCaT (Keratinocytes) | – | Gupta et al. (2016), Monnappa et al. (2016) |
| HepG2 (Liver epithelial) | |||
| HK-2 (Kidney epithelial) | |||
| MD (Spleen monocytes) | |||
| THP-1 (Blood monocytes) | |||
| T84, Caco2 (Colon carcinoma) | |||
| NuLi-1 (Alveolar epithelial) | |||
| Mice | Blood vessel (Intravenous) | – | Shatzkes et al. (2015) |
| Lung (Intranasal) | – | Shatzkes et al. (2015) | |
| Skin (Full-thickness skin wound) | – | Liu et al. (2022), Tajabadi et al. (2022) | |
| Raw 264.7 (Murine monocytes) | |||
| Rabbit | Eye (Ocular surface) | – | Romanowski et al. (2016) |
| Rat | Gut (Intrarectal) | – | Shatzkes et al. (2017) |
| Lung (Intranasal) | – | Shatzkes et al. (2016) | |
| Zebrafish | Larval microinjection (Hindbrain, Tail muscle, Caudal vein) | – | Willis et al. (2016) |
aActivity (–)—no loss in viability observed