Fig. 3. Selection of candidate complexes.

a The 376 candidate complexes were manually screened for complexes where the SSP blocks the active site of the hydrolase with an intrinsic fold. b The remaining 36 candidate complexes included 13 complexes between Kazal-like inhibitors and P69B and cystatin-like inhibitors with Pip1, and 23 candidate complexes with other candidate inhibitors. c Of the 23 remaining candidate complexes, transcriptome analysis of infected plants showed that genes encoding eight SSPs are not expressed at the tested conditions, whereas genes encoding 11 SSPs are expressed during infection. No transcriptomic datasets were available for Xp (4 SSPs). d Distribution of the final 15 candidate hydrolase-inhibitor complexes over the tested tomato pathogens and target hydrolases.