. 2023 Sep 6;15(18):3884. doi: 10.3390/nu15183884

Table 5.

Summary of Uros metabolites identified in the brain.

Animals	Route of Administration	Treatment	Brain Tissue	Identified Metabolites in Brain	Plasma Concentratio	Refs
male C57BL/6 mice (7 months, 25–30 g)	i.g.	UroA 0.3 mg/mouse, single administration	brain tissues	mUroA: 8 ng/g	---	[147]
male C57BL/6 mice (6 weeks)	i.g.	UroA 200 mg/kg b.w., single administration	cortex	UroA: 28 ng/g	15 ng/mL	[148]
male C57BL/6 mice (6 weeks)	i.g.	UroA 200 mg/kg b.w., single administration	hippocampus	UroA: 35 ng/g	15 ng/mL	[148]
male rats (12 weeks, 288 ± 20 g)	i.v.	Polyphenol metabolites (12.5 μg UroA + 5.3 μgUroB) 2.7 µmol/rat/day for 2 days	brain tissues	UroA: 2.2 ng/g	---	[41]
male rats (12 weeks, 288 ± 20 g)	i.v.		brain tissues	UroB: 0.5 ng/g	---	[41]
male albino Wistar rats (6 weeks, 250–300 g)	i.g.	Pomegranate juice 500 mg/kg b.w./day for 10 days	brain tissues	UroA: 1.68 ± 0.25 ng/g	18.75 ± 3.21 ng/mL	[36]
male albino Wistar rats (6 weeks, 250–300 g)	i.g.	Pomegranate juice 500 mg/kg b.w./day for 45 days	brain tissues	UroA: 2.068 ± 0.274 ng/g	---	[149]

Abbreviations: i.v.: intravenous, i.g.: intragastrical, b.w.: body weight.