Table 2.

Engineered bacteriophages carrying effector proteins.

Phage	Lifecycle	Target Bacteria	Carrying Gene	Potency
Lambda	Temperate	E. coli	Antibiotic susceptible wild-type gene (rpsL for streptomycin/gyrA for nalixidic acid)	Sensitize the antibiotics by complementing the antibiotic susceptible wild-type gene	[201]
Lambda	Temperate	E. coli	CRISPR-associated genes (cas3, cse1, cse2, cas7, cas5, and cas6e) and spacer targetting ß-lactamases (ndm and ctx)	Sensitize the antibiotics by destroying antibiotic resistance conferring plasmids	[202]
ФCD24-2	Temperate	C. difficile	Spacer sequence targeting bacterial chromosome	Dual-faceted potency: CRISPR-Cas induced irreversible genomic impairment and phage lysis module mediated cellular lysis	[203]
M13	Chronic	E. coli	SOS response repressor, lexA3	Augmenting antibiotic potency by suppression of SOS response	[205]
T7	Lytic	E. coli	Quorum-quenching enzyme, AiiA	Biofilm degradation by degrading acyl homoserine lactones and bactericidal effect of inherent lytic potency of T7	[206]
T7	Lytic	E. coli	Biofilm detachment enzyme, DspB	Biofilm detachment by hydrolysis of N-acetyl-D-glucosamines found in the biofilm matrices using DspB and bactericidal effect of inherent lytic potency of T7	[207]
K1F	Lytic	E. coli	SpyTag	Provide versatility by tagging a variety of materials	[208]