Table 3.
Estimated means of anthropometric, clinical and laboratory parameters over the study period.
| Parameters | Study period | ||
|---|---|---|---|
| T0 | T3 | T6 | |
| Body weight (kg) | 75.3 ± 1.9 | 72.2 ± 1.9** | 71.6 ± 1.9** |
| Body mass index (kg/m2) | 28.2 ± 0.6 | 27.1 ± 0.5** | 26.8 ± 0.6** |
| Waist circumference (cm) | 102.1 ± 1.4 | 99 ± 1.3** | 98.5 ± 1.5** |
| Heart rate (bpm) | 74.5 ± 1.8 | 77.7 ± 2.4 | 75.7 ± 1.9 |
| Systolic Blood Pressure (mmHg) | 128.7 ± 2.3 | 124.8 ± 2.7 | 121.9 ± 2.6* |
| Diastolic Blood Pressure (mmHg) | 74.9 ± 1.7 | 73.5 ± 1.6 | 75.4 ± 1.7 |
| Fasting glycemia (mg/dL) | 119.7 ± 4.1 | 112.7 ± 4.5 | 104.5 ± 4.0**# |
| Glycated hemoglobin (mmol/mol) | 46.1 ± 1.0 | 43.6 ± 1.3** | 41.9 ± 1.3**# |
| eGFR (mL/min/1.73 m2) | 78.2 ± 3.1 | 81.5 ± 4.3 | 79.3 ± 4.2 |
| Pancreatic isoamylase (IU/L) | 35.2 ± 3.6 | 45.4 ± 5.9 | 42.4 ± 3.9 |
| Lipase (IU/L) | 236.3 ± 36.9 | 192.4 ± 38.2 | 243.2 ± 32.7 |
| Total Cholesterol (mg/dL) | 154.4 ± 4.8 | 140.8 ± 3.8** | 139.2 ± 3.6** |
| LDL Cholesterol (mg/dL) | 75.7 ± 4.2 | 67.0 ± 3.2* | 65.7 ± 2.7* |
| HDL Cholesterol (mg/dL) | 55.6 ± 2.5 | 52.5 ± 2.3 | 51.6 ± 2.2 |
| Triglycerides (mg/dL) | 122.6 ± 12 | 121.2 ± 10.8 | 111.6 ± 9.0 |
| HOMA-IR index | 4.2 ± 1.2 | 3.3 ± 0.6 | 3.2 ± 0.7 |
| AST (IU/L) | 22.9 ± 2.1 | 25.1 ± 3.8 | 23.3 ± 2.6 |
| ALT (IU/L) | 28.7 ± 2.5 | 27.7 ± 4.1 | 23.7 ± 2.3* |
| γGT (IU/L) | 33.2 ± 3.6 | 28.1 ± 4.4 | 37.6 ± 9.5 |
| FLI | 61.1 ± 4.2 | 51.2 ± 4.3** | 52.8 ± 4.6** |
| HSI | 37.1 ± 0.7 | 36.9 ± 0.7 | 36.9 ± 0.7 |
| APRI | 0.13 ± 0.02 | 0.15 ± 0.04 | 0.13 ± 0.03 |
| FIB4 | 1.6 ± 0.2 | 1.8 ± 0.3 | 1.8 ± 0.3 |
Parameters are expressed as mean ± S.E. Estimated changes were analyzed at different times. Change versus T0: *p<0.05; **p<0.001. Change at T6 versus T3: #p<0.05. HOMA-IR: HOMA-IR, HOmeostasis Model Assessment of Insulin Resistance; LDL, Low-Density Lipoprotein; HDL, High-Density Lipoprotein; eGFR, estimated Glomerular Filtration Rate; AST, ASpartate aminoTransferase; ALT, ALanine aminoTransferase; γGT, gamma-Glutamyl Transferase; FLI, Fatty Liver Index; HSI, Hepatic Steatosis Index; APRI, Aspartate aminotransferase to Platelet Ratio Index; FIB4, Index for Liver Fibrosis.