Figure 2.

Progressive regulation of Aβ deposition in 3xTg-AD mouse brains treated with Nosustrophine. Comparative photomicrographs showing representative cortical and hippocampal brain sections of 3–9-month-old EB/3xTg-AD mice immunostained for Aβ. Images are presented according to the age group. (A–D) Images of mice given Nosustrophine show early A-immunoreactive plaques in the cortical and hippocampus regions, whereas control sections display multiple A-immunoreactive plaques with a compact morphology at various stages; (E) nosustrophine-treated wild-type mice’s control brain slice, demonstrating no negative effects; (F) cortical slices of the control brain of EB/3Tg-AD transgenic mice are heavily marked by A-immunoreactive plaques that have a large diameter and a compact central core. Scale bar: 100 μm.