Figure 3.

Nosustrophine modulates cortical density of β-amyloid plaques in early stages of AD mouse models. Comparative photomicrographs showing representative 3- and 9-month-old EB/3xTg-AD mouse brain sections stained by immunofluorescence antibody against β-amyloid. (A,C) Images showing the progressive accumulation of β-amyloid immunoreactive plaques in cortical regions of EB/3xTg-AD transgenic mice with no treatment (PBS); (B,D) in contrast, EB/3xTg-AD transgenic mice treated with Nosustrophine show a lower density of β-amyloid immunoreactive plaques in the early and middle stages of brain development. For abbreviations, see list. Scale bar: 100 μm.