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. 2023 Sep 15;16(9):1306. doi: 10.3390/ph16091306

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Nosustrophine regulate astrogliosis in AD mouse brains. Comparative photomicrographs showing representative brain regions of 4–9-month-old EB/3xTg-AD mice brain sections immunostained for GFAP. Images are presented according to the age group. (A–D) Images showing the progressive accumulation of dystrophic reactive astrocytes from the dentate gyrus to the external layers of the neocortex. Note the contrast in astrocytosis density between Nosustrophine-treated mice and controls, where numerous immunoreactive GFAP clusters are observed; (E) control brain section of wild-type mice treated with Nosustrophine, showing no adverse effects; (F) control brain section of EB/3xTg-AD transgenic mice showing numerous inflammatory GFAP-immunoreactive cell clusters in the cortical and hippocampal brain areas. Scale bar: 100 μm.