Figure 6.

Nosustrophine effect on neuropathological hallmarks in AD mouse models. Comparative photomicrographs showing representative 3 and 9-month-old EB/3xTg-AD mouse brain sections, early and middle stages of brain development, stained by antibodies against NeuN (neuronal nuclei), Cox2 (apoptosis), IL17 (proinflammatory cytokines), and TH (catecholaminergic neurons). (A–E) Images of hippocampal regions showing the progressive accumulation of AD pathological markers in control (not treated) mice; (B,D) when compared with wild-type mice (A) and 3xTg-Ad treated with Nosustrophine (C,E); (F–J) Images of midbrain regions showing the massive accumulation of AD pathological markers in control (not treated) mice; (G,I) when compared with wild-type mice (F) and 3xTg-Ad treated with Nosustrophine (H,J). Scale bar: 100 μm.