Table 2.
All quantified BAs reported as mean ± standard error of mean, or median (interquartile range) as appropriate. p value: for the comparison between pathological vs. controls. Primary BAs: sum of CA and CDCA. Secondary BAs: sum of DCA, LCA, α-MUCA and β-MUCA. Oxo-BAs: sum of all oxo-BAs quantified. Non-oxo-BAs: sum of all primary and secondary BAs. Total BAs: sum of all quantified BA concentrations.
| Pathological Subjects (n = 16) μg/g | Control Subjects (n = 16) μg/g | p-Value | |
|---|---|---|---|
| Primary BAs | |||
| CA + CDCA | 605 ± 211 | 8 [4–125] | 0.032 |
| CA | 530 ± 189 | 51 ± 19 | 0.017 |
| CDCA | 3.6 [0.01–111.8] | 0.01 [0.01–7.76] | 0.057 |
| Secondary BAs | |||
| DCA + LCA + UDCA + α-MUCA + β-MUCA | 594 [84–1106] | 1001 [190–1537] | 0.4230 |
| DCA | 496 [5–951] | 699 [7–1216] | 0.896 |
| LCA | 77.07 [0.09–203.2] | 171 ± 36 | 0.137 |
| UDCA | 0.63 [0.01–5.55] | 1.9 [0.01–4.49] | >0.999 |
| α-MUCA | 1.4 [0.8–3.5] | 0.30 [0.01–4.00] | 0.218 |
| β-MUCA | 3.65 [0.03–41.83] | 0.01 [0.01–1.74] | 0.021 |
| Oxo-BAs | 79 [35–411.4] | 216 ± 40 | 0.386 |
| 12-oxo-CA | 0.41 [0.01–4.06] | 0.56 [0.01–2.57] | 0.946 |
| 7-oxo-CA | 12 [1–128] | 27 ± 10 | 0.545 |
| 3-oxo-CDCA | 0.43 [0.01–2.11] | 0.01 [0.01–1.15] | 0.126 |
| 7-oxo-CDCA | 15 ± 5 | 0.01 [0.01–5.21] | 0.198 |
| 12-oxo-DCA | 16.02 [0.01–97.97] | 94 ± 25 | 0.233 |
| 3-oxo-DCA | 4.70 [0.01–40.25] | 48 ± 13 | 0.117 |
| 3,12-dioxo-DCA | 1.55 [0.01–3.24] | 7 [2–37] | 0.007 |
| 3-oxo-LCA | 0.01 [0.01–2.36] | 10± 3 | 0.017 |
| 3-oxo-UDCA | 0.01 [0.010–0.36] | 0.01 [0.01–0,01] | 0.434 |
| Non-oxo-BAs | 1027 [682–2221] | 879 [264–1426] | 0.361 |
| Total BAs | 1102 [733–3041] | 1076 [407–1723] | 0.539 |