Table 5.
Whole-exome sequencing comparison of mutations in MDD patients, their relatives, and healthy controls.
| Gene | Disease | MDD Mutation | Rs | Healthy Mutation | Rs | ||
|---|---|---|---|---|---|---|---|
| Patient | Relative | Female | Male | ||||
| ATP Binding Cassette Transporter G1 (ABCG1) [114] | Major depressive disorder (MDD) | / | - | rs- | - | - | - |
| Acetylserotonin O-Methyltransferase (ASMTL) [115] | Recurrent depressive disorder | / | / | rs13329185 | - | - | - |
| Calcium Voltage-Gated Channel Subunit Alpha1 F (CACNA1F) [116] | Psychiatric disorders | / | - | rs371501501 | - | - | - |
| Calcium Voltage-Gated Channel Subunit Alpha1 I (CACNA1I) [116] | Psychiatric disorders | / | - | rs- | - | / | rs- |
| Calcium Voltage-Gated Channel Auxiliary Subunit Alpha 2 Delta 2 (CACNA2D2) [117] | Schizophrenia | - | / | rs- | - | - | - |
| Cytochrome C Oxidase Subunit 7A1 (COX7A1) [118] | Neurodegeneration | / | rs112834485 | / | - | rs755756126 | |
| Cytochrome C Oxidase Subunit 7A2 (COX7A2) [118] | Neurodegeneration | / | / | rs554727448 | - | - | - |
| Glutamate Ionotropic Receptor Delta Type Subunit 2 (GRID2) [119] | Depolarization of neurons | / | - | rs- | - | - | - |
| 5-Hydroxytryptamine Receptor 3E (HTR3E) [120] | Schizophrenia | / | / | rs150341032 | - | / | rs187832026 |
| SH3 And Multiple Ankyrin Repeat Domains 2 (SHANK2) [121] | Neurodevelopmental disorder | / | / | rs35132270 | - | - | - |
| Tryptophan Hydroxylase-2 (TPH2) [122] | MDD | / | - | rs397897324 | - | - | - |