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. 2023 Aug 28;19(14):4644–4656. doi: 10.7150/ijbs.84108

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Galectin-9 (Gal-9) and p-STING are upregulated in post-chemotherapy surgical breast cancer specimens. (a) The images of IHC staining of p-STING and Gal-9 in human breast cancer tissues (n=104). Scale bar, 50 μm. (b) Gal-9 and p-STING staining in paired pre- and post-treatment of anthracycline samples show increased expression in post-treatment samples (P = 0.01). (c) A proposed model illustrating the mechanism of anthracyclines-induced immunosuppression is mediated by STING/Gal-9 axis in breast cancer.