Figure 1.

PHB2 overexpression attenuates LPS-induced myocardial depression. WT mice and PHB2 transgenic (PHB2^Tg) mice were administered LPS to induce endotoxemia-related myocardial dysfunction. (A-F) Analysis of cardiac function via echocardiography. (G-I) Serum levels of TnT, CK-MB, and BNP were determined by ELISA. (J) Histopathological evaluation of cardiac tissue (HE staining). (K) Electron microscopy (EM) was applied to observe ultrastructural changes in myocardium. Cardiomyocyte swelling, fragmented cardiomyocyte nuclei, and twisted myocardial fibers are marked with red arrows. (L, M) RT-qPCR analysis of the transcription of CXCR7 and TNFα in cardiac tissue. #p<0.05 vs. PBS+WT group; *p<0.05 vs. LPS+WT group.