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Pgam5 deletion restores mitophagy and UPRmt in LPS-challenged cardiomyocytes. Cultured HL-1 cells were co-transfected with sh/Pgam5 (or sh/Ctrl) and phospho-defective PHB2S39A mutant protein prior to LPS exposure. (A-C) RT-qPCR analysis of Beclin1, FUNDC1, and Parkin transcription levels. (D-G) RT-qPCR analysis of the transcription of mtDnaJ, ClpP, LonP1, and Hsp10. #p<0.05 vs PBS+sh/Ctrl group; *p<0.05 vs. LPS+sh/Ctrl group; @p<0.05 vs. LPS+sh/Pgam5 group.
