Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 28;19(14):4657–4671. doi: 10.7150/ijbs.85767

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Pgam5 deletion improves myocardial function in LPS-treated mice. WT mice and cardiomyocyte-specific Pgam5 knockout (Pgam5^Cko) mice were administered LPS to induce endotoxemia-related myocardial dysfunction. (A-F) Analysis of cardiac function via echocardiography. (G-I) Serum levels of TnT, CK-MB, and BNP were determined by ELISA. (J) Cardiac histopathology analysis by HE staining. (K) Electron microscopy (EM) was applied to analyze ultrastructural changes in myocardium. Cardiomyocyte swelling, fragmented cardiomyocyte nuclei, and twisted myocardial fibers are marked with red arrows. (L, M) RT-qPCR analysis of CXCR7 and TNFα mRNA levels in heart tissues. #p<0.05 vs. PBS+Pgam5^Cko group; *p<0.05 vs. LPS+Pgam5^Cko group.