Figure 8.

Use case 4: providing mechanistic insights for AOPs. Aop:38 relates how protein alkylation can lead to liver fibrosis (AO:344), which maps to liver cirrhosis (MESH:D008102) in CTD, with several prototypical stressors, including carbon tetrachloride (AOP stressor:13). Querying CTD Tetramers with carbon tetrachloride and liver cirrhosis generates 236 tetramers composed of 75 genes and 68 phenotypes, with many of the returned phenotypes reflecting the individual KE modules, providing potential mechanistic insights and literature-supported evidence for the causal subnetworks for each KE.