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. 2023 Jul 24;195(2):155–168. doi: 10.1093/toxsci/kfad069

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Figure 9. — Use case 4: proposing AOP networks. Four KEs (highlighted) used in Aop:38 are matched to corresponding CTD phenotypes, and these phenotypes are used to query CTD Tetramers independently to return 4 sets of tetramers for each phenotype. The diseases associated with each phenotype from the 4 sets of returned tetramers are compared in Venn analysis to discover 10 overlapping diseases shared by all 4 queries. Among the 10, hypertension corresponds to AO:952 and mesothelioma corresponds to AO:1090 in the AOP-Wiki; currently, there is no AO term for prostate cancer. These 4 KEs may be used to create new or augment existing independent AOPs leading to 4 different diseases, allowing an interconnected AOP network to be postulated. (Note: the additional MIEs and KEs necessary for each proposed independent AOP are not known/shown).