Table 2.
Phenotypes from 203 CGPD-tetramers connecting PFAS exposure with asthma, manually grouped into phenotype modules
| Phenotype | No. associated tetramers | No. associated genes | Phenotype module |
|---|---|---|---|
| Cellular response to xenobiotic stimulus | 8 | 8 | Cell response to stimulus |
| Cellular response to DNA damage stimulus | 3 | 3 | Cell response to stimulus |
| Response to tetrachloromethane | 1 | 1 | Cell response to stimulus |
| Cell redox homeostasis | 3 | 3 | Oxidative stress events |
| Peroxisome | 3 | 3 | Oxidative stress events |
| Superoxide dismutase activity | 2 | 2 | Oxidative stress events |
| Positive regulation of reactive oxygen species biosynthetic process | 1 | 1 | Oxidative stress events |
| Regulation of gene expression | 4 | 4 | Cell signaling |
| Positive regulation of p38MAPK cascade | 2 | 2 | Cell signaling |
| Positive regulation of protein import into nucleus | 2 | 2 | Cell signaling |
| Positive regulation of SMAD protein signal transduction | 2 | 2 | Cell signaling |
| Positive regulation of cytosolic calcium ion concentration | 1 | 1 | Cell signaling |
| Positive regulation of protein export from nucleus | 1 | 1 | Cell signaling |
| Progesterone secretion | 1 | 1 | Cell signaling |
| Inflammatory response | 14 | 9 | Immune/inflammatory response |
| Immune response | 8 | 8 | Immune/inflammatory response |
| Negative regulation of inflammatory response | 3 | 3 | Immune/inflammatory response |
| Microglial cell activation | 2 | 2 | Immune/inflammatory response |
| Positive regulation of cytokine production involved in inflammatory response | 2 | 2 | Immune/inflammatory response |
| Positive regulation of innate immune response | 1 | 1 | Immune/inflammatory response |
| Apoptotic process | 9 | 9 | Cell death |
| Positive regulation of apoptotic process | 9 | 9 | Cell death |
| Positive regulation of cell death | 2 | 1 | Cell death |
| Activation of cysteine-type endopeptidase activity involved in apoptotic process | 1 | 1 | Cell death |
| Positive regulation of neuron death | 1 | 1 | Cell death/nervous system |
| Positive regulation of cell migration | 6 | 6 | Cell migration |
| Cell chemotaxis | 4 | 4 | Cell migration |
| Cell migration | 4 | 4 | Cell migration |
| Chemotaxis | 3 | 3 | Cell migration |
| Cell adhesion | 3 | 3 | Cell process |
| Cell-cell adhesion | 3 | 3 | Cell process |
| Positive regulation of epithelial to mesenchymal transition | 3 | 3 | Cell process |
| Establishment of endothelial barrier | 1 | 1 | Cell process |
| Establishment of Sertoli cell barrier | 1 | 1 | Cell process |
| Positive regulation of cell population proliferation | 13 | 7 | Cell proliferation |
| Negative regulation of cell population proliferation | 7 | 7 | Cell proliferation |
| Cell population proliferation | 5 | 3 | Cell proliferation |
| Negative regulation of mitotic cell cycle | 3 | 3 | Cell proliferation |
| Cell growth | 2 | 1 | Cell proliferation |
| Stem cell proliferation | 2 | 2 | Cell proliferation |
| Mitotic cell cycle | 1 | 1 | Cell proliferation |
| DNA methylation | 1 | 1 | DNA methylation |
| DNA methylation involved in embryo development | 1 | 1 | DNA methylation |
| DNA methylation on cytosine within a CG sequence | 1 | 1 | DNA methylation |
| Cholesterol metabolic process | 4 | 2 | Metabolism |
| Lipid metabolic process | 4 | 3 | Metabolism |
| Triglyceride metabolic process | 4 | 2 | Metabolism |
| Glutathione metabolic process | 3 | 3 | Metabolism |
| Glucose homeostasis | 2 | 1 | Metabolism |
| Glutathione derivative biosynthetic process | 2 | 2 | Metabolism |
| Metabolic process | 2 | 2 | Metabolism |
| Negative regulation of protein catabolic process | 2 | 2 | Metabolism |
| Aerobic respiration | 1 | 1 | Metabolism |
| ATP biosynthetic process | 1 | 1 | Metabolism |
| Negative regulation of ATP biosynthetic process | 1 | 1 | Metabolism |
| Regulation of mitochondrial membrane potential | 2 | 2 | Mitochondrial |
| Mitochondrion organization | 1 | 1 | Mitochondrial |
| Cognition | 2 | 1 | Nervous system |
| Sensory perception of sound | 2 | 2 | Nervous system |
| Locomotory behavior | 1 | 1 | Nervous system |
| Memory | 1 | 1 | Nervous system |
| Regulation of blood pressure | 6 | 3 | Physiology/development |
| Determination of adult lifespan | 2 | 2 | Physiology/development |
| Bone mineralization | 1 | 1 | Physiology/development |
| Developmental growth | 1 | 1 | Physiology/development |
| Negative regulation of adipose tissue development | 1 | 1 | Physiology/development |
| Ovarian follicle development | 4 | 4 | Reproduction |
| Decidualization | 1 | 1 | Reproduction |
| Ovulation | 1 | 1 | Reproduction |
| Spermatogenesis | 1 | 1 | Reproduction |