Table 1.
Main demographic and clinical characteristics of the study patients.
| Characteristics | Value |
|---|---|
| Age, y, median (range) | 45.8 (9–72) |
| Male sex, n (%) | 16 (40%) |
| Weight, Kg, median (range) | 59 (35–96) |
| Disease type (%) | |
| Diffuse large B-cell lymphoma | 8 (20%) |
| Acute myeloid leukemia | 10 (25%) |
| Natural/killer T-cell lymphoma | 2 (5%) |
| Follicular lymphoma | 2 (5%) |
| Aplastic anemia | 2 (5%) |
| T-cell lymphoblastic lymphoma | 2 (5%) |
| Mixed-phenotype acute leukemia | 2 (5%) |
| Hemophagocytic syndrome | 4 (10%) |
| Sepsis | 2 (5%) |
| Fungal sinusitis | 2 (5%) |
| Pulmonary mycosis | 4 (10%) |
| IFD | |
| Invasive aspergillosis | 12 (30%) |
| Invasive candidiasis | 2 (5%) |
| Invasive mucormycosis | 12 (30%) |
| Unknown | 14 (35%) |
| Morbidities | |
| Diabetes mellitus | 10 (25%) |
| Hepatic insufficiency | 8 (20%) |
| Renal insufficiency | 16 (40%) |
| Graft-versus-host disease | 6 (15%) |
| Respiratory failure | 4 (10%) |
| Autologous | 6 (15%) |
| Allogeneic | 10 (25%) |
| Site of infection | |
| Pulmonary | 36 (90%) |
| Paranasal sinuses | 4 (10%) |
| Respiratory tract | 2 (5%) |
| Bloodstream infections | 6 (15%) |
| Classifications—IFD | |
| Proven | 2 (5%) |
| Probable | 24 (60%) |
| Possible | 14 (35%) |
| Outcome | |
| Diagnosis of IFD | |
| Partial remission | 30 (75%) |
| Progression | 7 (10%) |
| Dead | 3 (15%) |
| Type of IFD | |
| Invasive aspergillosis | 8/12 (66.7%) |
| Invasive candidiasis | 0/2 (0%) |
| Invasive mucormycosis | 10/12 83.3%) |
| Site of infection | |
| Pulmonary | 26/36 (72.2%) |
| Paranasal sinuses | 4/4 (100%) |
| Respiratory tract | 2/2 (100%) |
| Bloodstream infections | 6/8 (75%) |
| Therapy | |
| Target treatment | 18/26 (69.2%) |
| Empirical treatment | 12/14 (85.7%) |