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. 2023 Aug 31;15(9):1847. doi: 10.3390/v15091847
Summary of Section 7: Diagnosis of FIP; Section 7.2: Approach to the Diagnosis of FIP:
 If an effusion is present, sampling it is the single most useful diagnostic step because tests on effusions have a higher diagnostic value compared to those on blood samples. Samples of effusion can be easy to obtain; imaging (especially ultrasonography) is used to confirm, identify, localise, and sample smaller volumes. FIP effusions are usually clear, viscous/sticky and straw-yellow in colour.
Diagnosing FIP if there is no effusion present is more challenging due to the large number of possible clinical signs and their non-specific nature (e.g., anorexia, lethargy, weight loss, fever) and because biopsy collection ante-mortem can be very difficult due to, for example, problems accessing affected tissues, contra-indications for general anaesthesia or invasive biopsy collection in a sick cat, and/or costs involved in tissue collection. Cases with neurological or ocular signs can be approached via the sampling of cerebrospinal fluid or aqueous humour, but these techniques are not performed commonly outside of referral clinics. There is no non-invasive, confirmatory test available for cats with FIP that do not have effusions, although in some cases valuable supportive information can be gained through the analysis of fine-needle aspirate (FNA) samples collected from affected organs, if accessible. Tissue FNAs are usually easier to collect than tissue biopsies.
 The integration of multiple test results is most useful to help direct the clinician to a diagnosis of FIP being very likely, in the absence of confirmatory testing.