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. 2023 Sep 8;28(18):6528. doi: 10.3390/molecules28186528

Table 2.

Synthetic analogs of flavones and aurones with antimicrobial (antibacterial/antifungal/antiviral) properties.

Entry Chemical Structure Microbial Strains against the Tested Compounds Present Antimicrobial Activity Ref.
1 graphic file with name molecules-28-06528-i032.jpg Antifungal activity (inhibition zone for 50 μg/mL solution):
Aspergillus niger (IZ = 16 mm)
Penicillium italicum (IZ = 20 mm)
Fusarium oxysporum (IZ = 31 mm)		 [55]
2 graphic file with name molecules-28-06528-i033.jpg Antibacterial activity (inhibition zone for 50 μg/mL solution):
Staphylococcus aureus (IZ = 31 mm)
Pseudomonas aeruginosa (IZ = 11 mm)
Escherichia coli (IZ = 30 mm)		 [55]
3 graphic file with name molecules-28-06528-i034.jpg Antibacterial activity (inhibition zone for 50 μg/mL solution):
Staphylococcus aureus (IZ = 30 mm)
Bacillus subtilis (IZ = 11 mm)
Escherichia coli (IZ = 31 mm)
Antifungal activity (inhibition zone for 50 μg/mL solution):
Aspergillus niger (IZ = 13 mm)
Penicillium italicum (IZ = 24 mm)
Fusarium oxysporum (IZ = 25 mm)		 [55]
4 graphic file with name molecules-28-06528-i035.jpg Antibacterial activity (inhibition zone for 50 μg/mL solution):
Staphylococcus aureus (IZ = 33 mm)
Bacillus subtilis (IZ = 17 mm)
Escherichia coli (IZ = 33 mm)
Antifungal activity (inhibition zone for 50 μg/mL solution):
Aspergillus niger (IZ = 14 mm)
Penicillium italicum (IZ = 26 mm)
Fusarium oxysporum (IZ = 27 mm)		 [55]
5 graphic file with name molecules-28-06528-i036.jpg Antibacterial activity:
Staphylococcus aureus (MIC = 2 mg/L)
Escherichia coli (MIC = 4 mg/L)
Salmonella gallinarum (MIC = 0.125 mg/L)		 [56]
6 graphic file with name molecules-28-06528-i037.jpg Antibacterial activity:
Staphylococcus aureus (MIC = 1 mg/L)
Escherichia coli (MIC = 2 mg/L)
Salmonella gallinarum (MIC = 0.05 mg/L)
Listeria monocytogenes (MIC = 0.5 mg/L)		 [56]
7 graphic file with name molecules-28-06528-i038.jpg Antifungal activity (percentage inhibition at 0.25 mg/mL and, respectively 0.5 mg/mL concentration):
Acremonium strictum (81.33%; 100%)
Penicillium expansum (60.87%; 100%)
Aspergillus flavus (41.02%; 65.64%)		 [57]
8 graphic file with name molecules-28-06528-i039.jpg Antifungal activity (percentage inhibition at 0.25 mg/mL and, respectively 0.5 mg/mL concentration):
Acremonium strictum (70%; 100%)
Penicillium expansum (42.15%; 100%)
Aspergillus flavus (6.41%; 46.15%)		 [57]
9 graphic file with name molecules-28-06528-i040.jpg Antifungal activity (percentage inhibition at 0.25 mg/mL and, respectively 0.5 mg/mL concentration):
Acremonium strictum (76.88%; 100%)
Aspergillus flavus (15.38%; 60.51%)		 [57]
10 graphic file with name molecules-28-06528-i041.jpg Antifungal activity (percentage inhibition at 0.25 mg/mL and, respectively 0.5 mg/mL concentration):
Acremonium strictum (73.33%; 100%)		 [57]
11 graphic file with name molecules-28-06528-i042.jpg Antibacterial activity:
Staphylococcus aureus (MIC = 1.25 mg/mL)
Bacillus subtilis (MIC = 0.02 mg/mL)
Mycobacterium smegmatis (MIC = 0.625 mg/mL)
Antifungal activity:
Fusarium oxysporum (MIC = 0.625 mg/mL)		 [58]
12 graphic file with name molecules-28-06528-i043.jpg Antibacterial activity:
Staphylococcus aureus (MIC = 2.5 mg/mL)
Bacillus subtilis (MIC = 0.156 mg/mL)
Mycobacterium smegmatis (MIC = 0.078 mg/mL)
Anti biofilm and anti quorum sensing activity (100 μg/mL)
Antifungal activity:
Fusarium oxysporum (MIC = 0.313 mg/mL)
Candida albicans (MIC = 0.078 mg/mL)		 [58]
13 graphic file with name molecules-28-06528-i044.jpg Antibacterial activity (R=6-OCH3, 7-Cl)
Staphylococcus aureus (MIC = 1.25 mg/mL)
Bacillus subtilis (MIC = 1.25 mg/mL)
Klebsiella pneumoniae (MIC = 0.625 mg/mL)
Anti biofilm activity (R=6-OCH3, 100 μg/mL)
Antifungal activity (R=7-Cl):
Candida albicans (MIC = 0.156 mg/mL)		 [58]
14 graphic file with name molecules-28-06528-i045.jpg Antibacterial activity
Mycobacterium tuberculosis H37Rv
(MIC = 6.25 µg/mL)		 [35]
15 graphic file with name molecules-28-06528-i046.jpg Antiviral activity
Human cytomegalovirus (EC50 = 0.126 nM)		 [60]
16 graphic file with name molecules-28-06528-i047.jpg Antiviral activity
Chikungunya Virus (IC50 = 0.44 µM)		 [61]
17 graphic file with name molecules-28-06528-i048.jpg Antiviral activity
Chikungunya Virus (IC50 = 0.45 µM)		 [61]