Skip to main content
. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Med Chem. 2019 Oct 9;63(2):441–469. doi: 10.1021/acs.jmedchem.9b00640

Figure 14.

Figure 14.

The co-crystal structure of compound 62 bound to PI3Kδ (PDB 4XE0, 2.35 Å). Left Panel: Interaction of compound 62 with the protein. The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines; Right panel: The binding site of compound 62 in PI3Kδ. The protein surface is depicted in blue. Compound 62 atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.