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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Med Chem. 2019 Oct 9;63(2):441–469. doi: 10.1021/acs.jmedchem.9b00640

Figure 15.

Figure 15.

The co-crystal structure of compound 67a bound to PI3Kγ (PDB 4FLH, 2.6 Å). Left Panel: Interaction of compound 67a with the protein. The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines; Right panel: The binding site of compound 67a in PI3Kγ. The protein surface is depicted in blue. Compound 67a atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.