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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Med Chem. 2019 Oct 9;63(2):441–469. doi: 10.1021/acs.jmedchem.9b00640

Figure 16.

Figure 16.

The co-crystal structure of compound 71 bound to PI3Kγ (PDB 4WWN, 2.7 Å). Left Panel: Interaction of compound 71 with the protein. The protein is depicted as yellow ribbons, and hydrogen bonds are illustrated with blue dashed lines; Right panel: The compound 71 binding site in PI3Kγ. The surface of the protein is depicted in blue. Compound 71 atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.