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The co-crystal structure of compound 88 bound to EGFRT790M mutant (PDB 4G5P, 3.17 Å). The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound 88 atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet..
