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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Med Chem. 2019 Oct 9;63(2):441–469. doi: 10.1021/acs.jmedchem.9b00640

Figure 4.

Figure 4.

The co-crystal structure of compound 16 bound to c-MET (PDB 5EYD, 1.85 Å). Left panel: Interaction of compound 16 with the protein. The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines; Right panel: Compound 16 binding site in c-MET, protein is shown as surface. Compound 16 atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.