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The co-crystal structure of analogue 18c bound to c-MET (PDB 3R7O, 2.3 Å). Interaction of analogue 18c at the binding site of the protein. The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines. Compound 18c atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.
