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. Author manuscript; available in PMC: 2023 Sep 28.
Published in final edited form as: J Med Chem. 2019 Oct 9;63(2):441–469. doi: 10.1021/acs.jmedchem.9b00640

Figure 9:

Figure 9:

A. The co-crystal structure of compound 36a bound to TYK2 (PDB 6DBM, 2.36 Å). Left Panel: Interaction of compound 36a with TYK2, the protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines; Right panel: The binding site of compound 36a in TYK2. The surface of the protein is depicted in blue. B. The co-crystal structure of compound 36a bound to JAK1 (PDB 6DBN, 2.48 Å). Left Panel: Interaction of compound 36a with JAK1. The protein is depicted as yellow ribbons, and the hydrogen bonds are illustrated with blue dashed lines; Right panel: The compound 36a binding site in JAK1. The surface of the protein is depicted in blue. Compound 36a atoms are colored as follows: carbon, red-orange; nitrogen, blue; oxygen, red; chlorine, green; fluorine, jade; hydrogen, white; the chiral carbon is highlighted in violet.