Table 3.
Masitinib derivatives exhibit reduced cytostatic activity in A549 cells. The doubling time of A549 cells in the presence of DMSO or masitinib and its derivatives was calculated after fitting an exponential curve through data points generated from Figure 2A. ND = not determined.
| Doubling Time (h) | Dose | ||||
|---|---|---|---|---|---|
| 10 µM | 3 µM | 1 µM | 0.3 µM | ||
| COMPOUNDS | DMSO | 23.13 | ND | ND | ND |
| MWT | 347.8 | 74.57 | 24.94 | 22.72 | |
| M1 | 52.78 | 23.72 | 21.89 | 21.75 | |
| M2 | 33.63 | 21.57 | 21.44 | 21.52 | |
| M3 | 30.76 | 22.49 | 21.49 | 22.13 | |
| M4 | 37.36 | 22.28 | 21.47 | 22.01 | |
| M5 | 25.19 | 21.83 | 21.95 | 22.37 | |