Table 3.

Univariable analysis including receiver operating curves (ROC) and Chi² tests in order to determine significant prognostic biomarkers for the outcome of patients with COVID-19. We exclusively included parameters revealing a significant AUC ≥ 0.70 on ROC analysis or a statistically significant result on Chi² test.

Parameter	Prognostic for Class IIB and III (Siddiqi and Mehra) [12]	Prognostic for Class III and IV (WHO) [13]	Prognostic for COVID-19 Death
Ferritin	AUC 0.77, p < 0.0001 Criterion: >465, Youden index: 0.41	-	-
LDH	AUC 0.81, p < 0.0001 Criterion: >239, Youden index: 0.50	AUC 0.78, p < 0.0001 Criterion: >371, Youden index: 0.41	AUC 0.78, p < 0.0001 Criterion: >339, Youden index: 0.45
C-reactive protein	AUC 0.85, p < 0.0001 Criterion: >26, Youden index: 0.54	AUC 0.81, p < 0.0001 Criterion: >83, Youden index: 0.47	AUC 0.79, p < 0.0001 Criterion: >47, Youden index: 0.46
Age > 75 years	p < 0.0001	p < 0.0001	p < 0.0001
Diabetes	p = 0.014	-	p < 0.0001
Obesity	-	p = 0.0047	-
Cardiovascular diseases	p < 0.0001	p = 0.0004	p < 0.0001
Lung diseases	p = 0.006	p < 0.0001	p = 0.0073
Two or more comorbidities	p < 0.0001	p < 0.0001	p < 0.0001
Absolute eosinopenia	p < 0.0001	p < 0.0001	p < 0.0001
NLR	-	AUC 0.72, p < 0.0001 Criterion: >5.4, Youden index: 0.32	AUC 0.74, p < 0.0001 Criterion: >7.4, Youden index: 0.47
SII	-	-	AUC 0.70, p < 0.0001 Criterion: >1196, Youden index: 0.37