Figure 7.

(A) Schematic representation of ApoE3–rHDL action for Aβ clearance from microglia and astroglia after BBB permeation. (B) Brain distribution of ¹²⁵I-ApoE3–rHDL after intravenous administration. (C) ApoE3–rHDL rescued memory deficits in SAMP8 mice. (I) Escape latency, (II) swimming speed, (III) time spent in the quadrant where the escape platform is located, and (IV) representative swimming path. (* p < 0.05, ** p < 0.01, *** p < 0.001 significantly different with those of the saline treated SAMP8 mice.) (Adapted with permission from [136] Copyright © 2023, American Chemical Society, Washington, DC, USA).