Figure 1.

PS19 mice exhibit deficits in recognition and memory that are not improved by D-DPTIP. WT mice with vehicle treatment (N = 18), PS19 with vehicle treatment (N = 11), and PS19 with D-DPTIP treatment (N = 10) mice were used for behavioral tests. The treatment began when the mice were 4 months of age and lasted until they were 10 months old. (A) Discrimination index of NORT. Discrimination index = (time spent with novel object − time spent with familiar object)/total time. (B) Recognition index of NORT. Recognition index = time spent with novel object/total time. (C) Percentage of time spent in the Y-Maze novel arm. (D) Percentage of Y-Maze novel arm entries. (E) Time to fall in rotarod assessment, measured in seconds. Statistics were performed using one-way ANOVA in (A–E) with Tukey’s multiple comparisons. Bars represent mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.