Figure 7.

Tacrolimus exposure in adults: comparison of simulations using the adult PBPK model to selected clinical studies. (A) Möller et al. [3] as a reference study for a single IV administration (0.01 mg/kg). (B) Chen et al. [32] as a reference study for a single oral administration (0.075 mg/kg) to kidney transplant patients (C) Alloway et al. [34] as a reference study for tacrolimus exposure at steady state after oral administration of 2.85 mg in kidney transplant patients twice per day. In (B,C), the diffusion layer model was used to simulate dissolution. Full lines indicate the median simulated profile, dotted lines indicate the 5% and 95% percentile, and open circles represent the average reference data.