Table 6.
Performance of paediatric PBPK models for tacrolimus using different ontogeny functions. AFE = average fold error, AAFE = absolute average fold error, Slope = slope of the fold errors as a function of age. Lowest AAFE values are marked in bold.
| Model # | Ontogeny Profile and Fit | AUC | Cmax (ng/mL) | C0 (ng/mL) | ke (ng/mL/h) | Individual Timepoints | |
|---|---|---|---|---|---|---|---|
| 1 | Liver: Emoto ontogeny | AFE | 1.30 | 1.77 | 0.88 | 1.23 | 1.28 |
| Intestine: Johnson ontogeny | AAFE | 1.40 | 1.86 | 1.34 | 1.37 | 1.61 | |
| Extra fit: n/a | Slope | −0.05 | −0.13 | −0.01 | −0.02 | −0.06 | |
| 2 | Liver: Upreti ontogeny | AFE | 1.98 | 2.34 | 1.62 | 0.98 | 1.87 |
| Intestine: No ontogeny | AAFE | 1.99 | 2.34 | 1.66 | 1.32 | 2.14 | |
| Extra fit: n/a | Slope | −0.04 | −0.12 | 0.00 | −0.01 | −0.05 | |
| 3 | Liver: Upreti ontogeny | AFE | 1.10 | 1.44 | 0.78 | 1.18 | 1.11 |
| Intestine: Upreti ontogeny | AAFE | 1.30 | 1.52 | 1.46 | 1.34 | 1.51 | |
| Extra fit: n/a | Slope | 0.01 | −0.03 | 0.03 | −0.02 | 0.01 | |
| 4 | Liver: Upreti ontogeny | AFE | 0.90 | 1.24 | 0.59 | 1.26 | 0.94 |
| Intestine: Upreti ontogeny | AAFE | 1.30 | 1.38 | 1.79 | 1.40 | 1.58 | |
| Extra fit: Bmax fit | Slope | 0.03 | −0.01 | 0.04 | −0.03 | 0.02 |