Table 2.
Clinical characteristics of patients with secondary sarcomas and pathologic characteristics of the 108 tumors
| Characteristic | Value |
|---|---|
| Median age at primary diagnosis of childhood cancer, y (range) | 8 (1–20) |
| Median time from primary diagnosis to secondary sarcoma, y (range) | 11 (5–29) |
| Median age at secondary sarcoma, y (range) | 20 (8–49) |
| Age at diagnosis of secondary sarcoma, No. (%) | |
| 5–14 y | 24 (23) |
| 15–24 y | 48 (46) |
| 25–34 y | 25 (24) |
| ≥35 y | 7 (7) |
| Pathologic subtype of secondary sarcoma, No. (%) | |
| Non-rhabdomyosarcoma soft tissue sarcoma | 50 (46) |
| Osteosarcoma | 31 (29) |
| Malignant peripheral nerve sheath tumor | 19 (18) |
| Ewing/primitive neuroectodermal tumor | 5 (5) |
| Rhabdomyosarcoma | 3 (3) |
| Size of secondary sarcoma, No. (%) | |
| ≤5 cm | 32 (30) |
| >5 cm | 25 (23) |
| Unknown | 51 (47) |
| Site of secondary sarcoma, No. (%) | |
| Head and neck | 21 (19) |
| Trunk | 41 (38) |
| Extremities | 31 (29) |
| Pelvis | 8 (7) |
| Unknown | 7 (6) |
| Radiation exposure for treatment of primary cancer, No. (%) | |
| Second sarcoma in radiation field | 60 (56) |
| Second sarcoma distant from radiation field | 13 (12) |
| No radiation for primary cancer | 11 (10) |
| Unknown primary radiation data | 12 (11) |
| Unknown site of second sarcoma | 10 (9) |
| Cause of death of secondary sarcoma participants, No. (%)* | |
| Original cancer | 10 (17) |
| Secondary sarcoma | 39 (66) |
| Cardiac toxicity | 3 (5) |
| Unknown | 7 (12) |
*
Fifty-nine of the 104 patients with secondary sarcoma were deceased.