Table 2.
Characteristic | Value |
---|---|
Median age at primary diagnosis of childhood cancer, y (range) | 8 (1–20) |
Median time from primary diagnosis to secondary sarcoma, y (range) | 11 (5–29) |
Median age at secondary sarcoma, y (range) | 20 (8–49) |
Age at diagnosis of secondary sarcoma, No. (%) | |
5–14 y | 24 (23) |
15–24 y | 48 (46) |
25–34 y | 25 (24) |
≥35 y | 7 (7) |
Pathologic subtype of secondary sarcoma, No. (%) | |
Non-rhabdomyosarcoma soft tissue sarcoma | 50 (46) |
Osteosarcoma | 31 (29) |
Malignant peripheral nerve sheath tumor | 19 (18) |
Ewing/primitive neuroectodermal tumor | 5 (5) |
Rhabdomyosarcoma | 3 (3) |
Size of secondary sarcoma, No. (%) | |
≤5 cm | 32 (30) |
>5 cm | 25 (23) |
Unknown | 51 (47) |
Site of secondary sarcoma, No. (%) | |
Head and neck | 21 (19) |
Trunk | 41 (38) |
Extremities | 31 (29) |
Pelvis | 8 (7) |
Unknown | 7 (6) |
Radiation exposure for treatment of primary cancer, No. (%) | |
Second sarcoma in radiation field | 60 (56) |
Second sarcoma distant from radiation field | 13 (12) |
No radiation for primary cancer | 11 (10) |
Unknown primary radiation data | 12 (11) |
Unknown site of second sarcoma | 10 (9) |
Cause of death of secondary sarcoma participants, No. (%)* | |
Original cancer | 10 (17) |
Secondary sarcoma | 39 (66) |
Cardiac toxicity | 3 (5) |
Unknown | 7 (12) |
Fifty-nine of the 104 patients with secondary sarcoma were deceased.