Table 6.
Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways enriched in upregulated differentially expressed genes in liver samples from cows that were high feed efficient (HE; n = 12) compared with low feed efficient (LE; n = 12) 1.
| KEGG Pathway | ID | Genes | Fold Enrichment |
Corrected p-Value | Gene Symbols 2 |
|---|---|---|---|---|---|
| Cell cycle | bta04110 | 14 | 8.4 | 6.9 ×10−12 | BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CCNE2, CDC20, CDC25A, CDC6, CDK1, CDKN2C, ESPL1, ORC1, TTK |
| Cellular senescence | bta04218 | 8 | 4.8 | 0.00067 | CCNA2, CCNB1, CCNB2, CCNE2, CDC25A, CDK1, FOXM1, LOC787122 |
| Human T-cell leukemia virus 1 infection | bta05166 | 8 | 4.8 | 0.00540 | BUB1B, CCNA2, CCNB2, CCNE2, CDC20, CDKN2C, ESPL1, LOC787122 |
| p53 signaling pathway | bta04115 | 5 | 3.0 | 0.01500 | CCNB1, CCNB2, CCNE2, CDK1, RRM2 |
1 Enrichment analysis was performed using the Database for Annotation, Visualization, and Integrated Discovery (v. 2021) by comparing differentially expressed genes (mean read count ≥ 10; p-value ≤ 0.05; fold change ≥1.5). Fold enrichment and Benjamini corrected p-values are reported. 2 Annotation of gene transcripts and affiliated gene symbols are based on the Bos taurus reference genome (release 106, ARS-UCS 1.2).