Table I.
Subject characteristics at baseline of study population (N = 50)
| Variable | Study Population (N = 50) |
|---|---|
| Age (years) | 63.3 (6.5) |
| Females, n (%) | 37 (74) |
| Index knee, n (% Right) | 29 (58) |
| Body mass index (BMI) (kg/m2) | 28.7 (4.9) |
| Worst Kellgren–Lawrence grade (medial/lateral) in index knee | |
| Grade 1, n (%) | 8(16) |
| Grade 2, n (%) | 22 (44) |
| Grade 3, n (%) | 16 (32) |
| Grade 4, n (%) | 4(8) |
| WOMAC* pain score | 32.0 (17.7) |
| WOMAC stiffness score | 48.0 (22.5) |
| WOMAC function score | 35.9 (20.8) |
| WOMAC total score | 36.1 (19.3) |
| Total Synovial tissue volume (mm3) | 12,278.6 (6,185.0) |
| Total BML volume (mm3) | 7,117.1 (9,347.3) |
| Total Subchondral BML volume (mm3) | 6,434.5 (8,275.1) |
| Subchondral BMLs without a cyst-like component (mm3) | 4,417.0 (5,955.2) |
| Subchondral BMLs with a cyst-like component (mm3) | 2,017.5 (4,519.8) |
| Volume of the cyst-like component† (mm3) | 64.8 (254.9) |
| Total Ligament-based BML volume (mm3) | 682.6 (1,813.4) |
| Ligament-based BML without a cyst-like component (mm3) | 294.7 (1,096.9) |
| Ligament-based BMLs with a cyst-like component (mm3) | 387.9 (1,522.6) |
Results are shown as mean (SD) or frequencies (%).
Volumes reported here correspond to the mean, summed volumes of the given structure in those with the respective structure.
*
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): visual analogue scale (VAS) used to score pain, stiffness and total respectively from 0 to 100 units (0 = no pain/disability, 100 = high pain/disability).
†
Volume of the cyst-like component itself from subchondral BMLs with cyst-like components.