. Author manuscript; available in PMC: 2023 Sep 28.

Published in final edited form as: Osteoarthritis Cartilage. 2019 Dec 23;28(3):316–323. doi: 10.1016/j.joca.2019.12.002

Table II.

Association between BML volume (total, subchondral & ligament-based) and symptoms

MRI parameter	Outcome
	b (95% CI), P value
	WOMAC^† pain score	WOMAC stiffness score	WOMAC function score	WOMAC total score
Total BML volume^‡,^* (N = 45)	0.3 (−0.3 to 0.9), 0.26	0.2 (−0.5 to 0.9), 0.63	0.5 (−0.1 to 1.2), 0.11	0.5 (−0.1 to 1.0), 0.13
Total subchondral BML volume^‡,^* (N = 45)	0.3 (−0.3 to 1.0), 0.31	0.2 (−0.6 to 1.0), 0.64	0.5 (−0.2 to 1.2), 0.15	0.5 (−0.2 to 1.1), 0.16
Total ligament-based BML volume^‡,^* (N = 19)	1.9 (−1.6 to 5.3), 0.29	0.2 (−3.9 to 4.3), 0.93	2.8 (−1.0 to 6.5), 0.15	2.4 (−1.0 to 5.8), 0.17

All results presented with 95% confidence intervals (CI).

N-values correspond to the number of participants included in each analyses.

Volumes include cyst-like component volume.

^†

WOMAC index; range from 0 to 100 units with higher scores denoting worse pain and disability.

^‡

Beta coefficients are scaled to reflect a unit change in WOMAC score (0–100) for a 1 cm³ increase in volume in the structural parameter.