. Author manuscript; available in PMC: 2023 Sep 28.

Published in final edited form as: Osteoarthritis Cartilage. 2019 Dec 23;28(3):316–323. doi: 10.1016/j.joca.2019.12.002

Table III.

Association between subchondral BML volume, with or without a cyst-like component, and symptoms

MRI parameter	Outcome
	b (95% CI), P value
	WOMAC^†pain score	WOMAC stiffness score	WOMAC function score	WOMAC total score
Subchondral BMLs without a cyst-like component^‡ (N = 45)	−0.1 (−0.8 to 0.7), 0.86	0.2 (−0.7 to 1.0), 0.71	0.4 (−0.4 to 1.1), 0.37	0.3 (−0.5 to 1.0), 0.48
Subchondral BMLs with a cyst-like component^‡,^* (N = 17)	0.8 (−0.5 to 2.1), 0.21	−0.1 (−1.7 to 1.5), 0.92	0.1 (−1.3 to 1.6), 0.85	0.3 (−1.0 to 1.5), 0.68)
Volume of the cyst-like component in subchondral BML^‡ (N = 17)	51.8 (14.2 to 89.3), 0.01	22.0 (−26.2 to 70.3), 0.37	38.9 (−3.7 to 81.5), 0.07	40.2 (2.1 to 78.3), 0.04

All results presented with 95% confidence intervals (CI).

N-values correspond to the number of participants included in each analyses.

Volumes include cyst-like component volume.

^†

WOMAC index; range from 0 to 100 units with higher scores denoting worse pain and disability.

^‡

Beta coefficients are scaled to reflect a unit change in WOMAC score (0–100) for a 1 cm³ increase in volume in the structural parameter.