Table 2.
Crude analysis of factors associated with the all-cause mortality and GIST-related mortality among US patients between 2000 and 2017.
| Characteristics | Overall Mortality. Crude Proportional Hazard Ratio (95% Confidence Interval) |
GIST Mortality. Crude Proportional Hazard Ratio (95% Confidence Interval) |
|---|---|---|
| Gender | ||
| Female | 1 (reference) | 1 (reference) |
| Male | 1.53 (1.27–1.85) *** | 1.46 (1.09–1.95) ** |
| Age at diagnosis, y.o. | ||
| 0–39 | 1 (reference) | 1 (reference) |
| 40–59 | 1.92 (0.84–4.39) | 1.18 (0.51–2.75) |
| 60–79 | 3.72 (1.66–8.37) *** | 1.45 (0.64–3.32) |
| 80+ | 10.78 (4.74–24.50) *** | 3.08 (1.29–7.37) ** |
| Race | ||
| Non-Hispanic White | 1 (reference) | 1 (reference) |
| Non-Hispanic Black | 1.30 (1.04–1.62) ** | 1.77 (1.27–2.47) *** |
| Hispanic | 0.86 (0.62–1.20) | 1.04 (0.63–1.73) |
| Other | 0.78 (0.57–1.08) | 1.03 (0.64–1.66) |
| Cancer site | ||
| Colon | 1 (reference) | 1 (reference) |
| Esophagus | 1.55 (0.41–5.86) | 1.02 (0.11–9.15) |
| Stomach | 0.92 (0.45–1.85) | 0.65 (0.24–1.76) |
| Rectum | 0.80 (0.29–2.20) | 0.94 (0.23–3.74) |
| Small intestine | 1.08 (0.53–2.21) | 1.09 (0.40–2.97) |
| Other | 0.76 (0.20–2.86) | 1.00 (0.18–5.47) |
| Tumor stage | ||
| Localized | 1 (reference) | 1 (reference) |
| Regional via direct extension only | 1.41 (1.03–1.93) ** | 2.54 (1.62–3.99) *** |
| Regional lymph nodes involved only | 0.64 (0.16–2.56) | 0 |
| Regional via both direct extension and lymph node involvement | 3.03 (1.25–7.34) ** | 6.19 (1.96–19.57) *** |
| Distant | 3.77 (3.02–4.70) *** | 8.55 (6.26–11.68) *** |
| Living area | ||
| Counties in metropolitan areas of 1 million persons | 1 (reference) | 1 (reference) |
| Counties in metropolitan areas of 250,000 to 1 million persons | 1.12 (0.90–1.40) | 1.01 (0.70–1.44) |
| Counties in metropolitan areas of 250,000 persons | 1.24 (0.86–1.79) | 1.66 (1.01–2.75) ** |
| Nonmetropolitan counties adjacent to a metropolitan area | 1.54 (1.10–2.15) ** | 1.68 (1.01–2.77) ** |
| Nonmetropolitan counties not adjacent to a metropolitan area | 1.34 (0.88–2.04) | 1.22 (0.62–2.42) |
| Income per year | ||
| USD < 35,000 | 1 (reference) | 1 (reference) |
| USD 35,000–44,999 | 1.82 (0.90–3.69) | 2.56 (0.77–8.47) |
| USD 45,000–54,999 | 1.21 (0.61–2.42) | 1.27 (0.39–4.19) |
| USD 55,000–64,999 | 1.20 (0.61–2.37) | 1.77 (0.56–5.64) |
| USD 65,000–74,999 | 0.90 (0.45–1.81) | 0.95 (0.29–3.15) |
| USD 75,000+ | 0.92 (0.46–1.80) | 1.03 (0.32–3.33) |
| Marital status | ||
| Married | 1 (reference) | 1 (reference) |
| Single | 1.18 (0.91–1.54) | 1.44 (0.99–2.10) |
| Divorced/separated | 1.12 (0.81–1.55) | 1.11 (0.67–1.83) |
| Widowed | 2.50 (1.95–3.19) *** | 1.64 (1.06–2.55) ** |
| Radiation | ||
| No | 1 (reference) | 1 (reference) |
| Yes | 4.00 (1.00–16.07) | 4.75 (0.67–33.94) |
| Chemotherapy | ||
| No | 1 (reference) | 1 (reference) |
| Yes | 1.29 (1.07–1.55) *** | 2.83 (2.11–3.80) *** |
*** p < 0.01, ** p < 0.05.