Table 3.
Positive and Negative Correlations Involving Signature DTG-Selected DRMs 1.
DRM A | DRM B | A and B | A Alone | B Alone | Neither | Spearman Rho | p Value |
---|---|---|---|---|---|---|---|
Positively correlated DRMs 2 | |||||||
G140S | Q148H | 3 | 1 | 0 | 95 | 0.86 | <0.001 |
G140A | Q148K | 2 | 2 | 2 | 93 | 0.48 | <0.001 |
G140A | Q148R | 2 | 2 | 3 | 92 | 0.42 | <0.001 |
T66A | G118R | 5 | 0 | 23 | 70 | 0.37 | <0.001 |
S147G | N155H | 4 | 4 | 9 | 82 | 0.32 | 0.001 |
E157Q | R263K | 7 | 0 | 40 | 52 | 0.29 | 0.004 |
S147G | Q148R | 2 | 6 | 3 | 88 | 0.27 | 0.007 |
G118R | E138K | 8 | 17 | 8 | 62 | 0.24 | 0.02 |
L74M | G118R | 2 | 0 | 25 | 70 | 0.23 | 0.02 |
G140S | N155H | 2 | 2 | 11 | 84 | 0.22 | 0.03 |
T97A | N155H | 2 | 2 | 11 | 84 | 0.22 | 0.03 |
A49G | R263K | 4 | 0 | 43 | 52 | 0.22 | 0.03 |
L74I | G118R | 3 | 1 | 25 | 69 | 0.21 | 0.04 |
Negatively correlated DRMs 3 | |||||||
G118R | R263K | 3 | 24 | 42 | 28 | −0.44 | <0.001 |
E138K | R263K | 2 | 16 | 43 | 36 | −0.34 | <0.001 |
Q148KRH | R263K | 0 | 11 | 46 | 41 | −0.33 | <0.001 |
N155H | R263K | 2 | 11 | 45 | 41 | −0.25 | 0.01 |
G118R | N155H | 0 | 29 | 13 | 57 | −0.25 | 0.01 |
T66I | R263K | 0 | 6 | 47 | 46 | −0.24 | 0.02 |
G118R | Q148KRH | 0 | 28 | 11 | 59 | −0.23 | 0.03 |
Footnote: 1 DRMs present as part of mixtures were excluded from analysis. 2 Only those pairs present in ≥2 PLWH were analyzed. 3 For this analysis Q148H/K/R were pooled.