Table 1.
Characteristics of 11 studies of folate receptor-positive circulating tumour cells in the diagnosis of lung cancer, included in the meta-analysis.
| Author | Year | Country | Ethnicity | Age (range), years |
Patients/Controls | Control group | Method | Cut-off (U/ml) | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Patients | ||||||||||
| Chen1 6 | 2015 | China | Asian | 50 (15–85) | 59 (23–83) | 473/283 | Healthy/BLD | PCR | 8.93 | 74.4 | 86.6 |
| Chen2 6 | 2015 | China | Asian | 49 (15–85) | 59 (23–83) | 473/227 | BLD | PCR | 8.93 | 74.2 | 85 |
| Lian 7 | 2016 | China | Asian | 51 (37–66) | 61 (38–72) | 97/18 | BLD | PCR | 8.7 | 82.5 | 72.2 |
| Liu 8 | 2019 | China | Asian | 61 (34–80) | 47 (22–77) | 75/71 | Healthy/BLD | PCR | 7.9 | 78.7 | 81.7 |
| Liu 9 | 2021 | China | Asian | NA | 58 (46–70) | 184/39 | BLD | PCR | 8.7 | 89.1 | 92.3 |
| Lu 10 | 2020 | China | Asian | 56 (37–68) | 56 (42–77) | 22/15 | BLD | PCR | 8.7 | 72.7 | 93.3 |
| Lv 11 | 2022 | China | Asian | 49 (35–63) | 61 (50–71) | 282/256 | BLD | PCR | 8.9 | 81.9 | 80.9 |
| Wang 12 | 2017 | China | Asian | 44 (19–77) | 60 (21–79) | 197/171 | Healthy/BLD | PCR | 8.7 | 77.7 | 89.5 |
| Xue 13 | 2018 | China | Asian | 52 (27–65) | 61 (43–88) | 72/26 | Healthy/BLD | PCR | 8.7 | 81.94 | 73.08 |
| Yu 14 | 2013 | China | Asian | 45 (23–77) | 59 (25–85) | 153/113 | Healthy/BLD | PCR | 8.64 | 73.2 | 84.1 |
| Zhou 15 | 2019 | China | Asian | NA | NA | 169/53 | BLD | PCR | 8.3 | 79.88 | 75.47 |
Data presented as mean (range) or number of patients.
BLD, benign lung disease; PCR, polymerase chain reaction; NA, not available.