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. 2023 Sep 7;28(18):6484. doi: 10.3390/molecules28186484

Figure 1.

Figure 1

Principles of SDT for oncology treatment. (A) Ultrasound carries acoustic energy that can produce both thermal and non-thermal effects in the tumor region. The thermal effect can directly cause cellular damage. Non-thermal effects mainly occur as cavitation effects. (B) ROS generation. Ultrasound induces intracellular ROS generation inside the tumor by producing cavitation effects and activating sonosensitizers. (C) ROS cause tumor cell death by inducing cellular autophagy and necrosis, among other pathways. Created with BioRender.com (accessed on 23 August 2023).