Figure 3.

(A) Grayscale and color US images (B mode and Harmonic mode) of TRAMP cells implanted in the tumor before (left) and after (right) injection of PCF-MBs. The red arrows highlight the tumor sites. (B) In vivo B-mode US imaging. (4T1 tumor-bearing nude mice). (C) Corresponding grayscale values of tumors obtained 5 min after intratumoral injection of PBS, SiO₂ (10 mg/kg), MISO (5 mg/kg), and SMISO (15 mg/kg) (* p < 0.05, ** p < 0.01, n = 3, mean ± SD). Scale bar: 2 mm. (D) Before and after comparison of B-mode and CEUS-mode imaging with ultrasound irradiation. Notes: (A) Adapted with permission from Ref. [49]. Copyright 2018, American Chemical Society. (B,C) Adapted with permission from Ref. [66]. Copyright 2023, American Chemical Society. (D) Adapted with permission from Ref. [47]. Copyright 2019, American Chemical Society.