Table 1.

US Imaging Characteristics of the Multifunctional Sonosensitizers.

Sonosensitizers	Probes	Biological Model	SDT Result	Imaging Effect	Ref.
PCF-MBs	PCF	HT-29 cancer-bearing Balb/c nude mice	tumor inhibition rate of more than 50%	20 s post-injection, the US imaging signal reached the maximum; and the contrast enhancement could last for more than 3 min	[49]
FMSN-DOX	FMSNs	TRAMP tumor-bearing nude mice	The gradual reduction in tumor growth	from day 1 to day 9 with significant contrast enhancement within the tumor.	[45]
HMME/MCC-HA	MCC NPs	MCF-7 tumor-bearing nude mice	successfully suppressed the tumor volume with the V/V0 of 0.87 ± 0.13	strong US signals in tumor site at 3 h post-injection, and particularly after exposure to US stimulus	[8]
Lip-AIPH	AIPH	MCF-7 tumor-bearing mice	a highly significant antitumor effect was achieved in mice in the group of Lip-AIPH with US irradiation	a highly significant antitumor effect was achieved in mice in the group of Lip-AIPH with US irradiation	[62]
mTiO2@PPY-HNK	mTiO2	4T1 tumor model	significantly inhibit the tumor growth	as the concentration increases, the ultrasound signal is more intense and the image is clearer	[63]
OIX_NPs	PFP	ID8 cells into the left shoulder (the primary tumor)	significant inhibition of tumor volume	peaking at 4 h post-injection.	[64]
TPZ/HMTNPs-SNO	HMTNPs-SNO	MCF-7 tumor-bearing nude mice	exhibited an effective therapeutic effect	compared with the saline group, showed local enhancement at the tumor site.	[65]
IR780-NDs	PFP	breast cancer 4T1 nude mice	Tumor weight drop	24 h after the injection of IR780-NDs a bright US signal occurred at the tumor site.	[47]
SMISO NPs	SMISO	4T1 tumor-bearing nude mice	the inhibition rate of tumor growth in the SMISO + US group reached 88.2%	the grayscale values of US images increase with them. concentration increases	[66]
RPPs&SPIOs	RPPs	4T1 tumors	a 100% survival rate of mice at 90 days	Shift in RPPs after thermal stimulation results in significant contrast enhancement	[67]
FA-PEG-PLGA-Ptx@ICG-Pfh NPs	Pfh	MDA-MB231 tumor-bearing mice	tumor growth was significantly inhibited	images were greatly improved	[68]
RBC-HPBs/HMME/PFH	PFH	4T1 tumor-bearing female mice	enhancing tumor treatment effects of HMME	A clear US signal was observed at 4 h after injection, and the strongest signal appeared at 8 h.	[69]
Ce6-PFP-DTX/PLGA	PFP	breast cancer 4T1 nude mice	much higher inhibition rate of the CPDP NPs + LIFU group	after LIFU irradiation, the corresponding intensity of CPDP NPs was elevated compared with the pre-irradiation group	[70]
AS1411-DOX-PFH-PEG@PLGA	PFH	breast cancer 4T1 nude mice	the tumor volumes significantly decreased	Increased imaging ability of ADPPs in vivo within 24 h after intravenous injection	[71]
RB-MBs	MBs	HT-29 tumor mouse model	-	a contrast-enhanced ultrasound imaging mode at a frequency of 5 MHz	[72]