Table 3.

MR Imaging Characteristics of the Multifunctional Sonosensitizers.

Sonosensitizers	Probes	Biological Model	SDT Result	Imaging Effect	Ref.
UPFB	MOFs (Fe3+)	U14 tumor-bearing Kunming mice	increased inhibition of tumor growth	enhanced T2 contrast signal	[84]
Fe-TiO2 NDs	Fe3+	4T1 tumor-bearing mice	better tumor inhibition	The brightening effect through the T1-weighted MR images	[85]
Fe-VS2-PEG	Fe3+	4T1 cells subcutaneously in BALB/c mice	better treatment effect and a longer survival period	the tumor had an obvious brightening effect 24 h after i.v. injection (T1)	[83]
OCN-PEG-(Ce6-Gd3+)/BNN6	Ga3+	4T1 tumor-bearing mice	the tumor suppression rate reached 63.2%	The T1-weighted contrast effect was significantly enhanced	[52]
MnSiO3-Pt@BSA-Ce6(MPBC)	Mn2+	U14 tumor-bearing Balb/c mice	tumor growth inhibition	the T1−MR signal of the tumor enhanced	[86]
MG@P NPs	PMnC (Mn)	4T1 tumor-bearing mice	the tumor growth of Mice remarkably suppressed	T1 signal of the tumor region showed an increasing trend within 24 h and then decreased	[87]
F3-PLGA@MB/Gd NPs	Gd-DTPA-BMA	the nude mice bearing MDA-MB-231 tumors	induce tumor cell apoptosis	Linear signal dependence of T1 intensity values	[46]
Ang-IR780-MnO2-PLGA (AIMP)	MnO2	U87MG tumor-bearing mice	enhanced SDT effect	A linear relationship was shown between the 1/T1 values and Mn concentration	[88]
DOX/Mn-TPPS@RBCS	Mn-TPPS	MCF-7 tumor-bearing nude mice	Inhibit tumor growth	T1-weighted MR imaging results in enhancement	[89]
MnTTP-HSA	MnTTP (Mn)	MCF-7 tumor-bearing nude mice	the best in completely inhibiting tumor	a T1 the positive signal at the tumor showed an increasing trend within 3 h and then gradually decreased	[90]
mZMD	MnO2	HeLa tumor xenograft-bearing nude mice	significant suppression effects	the concentration of the NCs increased, the T1 MR images became brighter and brighter	[91]
GdHF-NDs	Ga3+	CT26 tumor-bearing mice	GdHF-NDs/PEG + US shows the most potent efficiency in tumor suppression (73.7%)	T1 signal strength increased	[78]