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. 2023 Sep 8;16(9):1272. doi: 10.3390/ph16091272

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mechanism of action of JAK inhibitors in IBD [95]. JAK blockade occurs in pairs involving five different inhibition scenarios interrupting STAT-mediated extracellular-nuclear communication. IL: Interleukin; JAK: Janus Kinase; GM-GSF: Granulocyte-macrophage colony-stimulating factor; INF: STAT: Signal transducer and activator of transcription proteins; INF: Interferon. Adapted with permission from Pippis, Elleni J; Yacyshyn, Bruce R, Inflammatory Bowel Diseases; published by Oxford University Press, 2020.