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A schematic graphic depicting the successive steps in the production of ghrelin gene products and their connection with GOAT. The ghrelin gene in humans is located on chromosome 3p25-26. The GHRL gene encodes the preproghrelin peptide, which is later transformed into des-acyl ghrelin (DAG) and obestatin. DAG is then modified enzymatically in the endoplasmic reticulum by GOAT to produce acyl-ghrelin. GOAT—ghrelin-o-acyltransferase.
